In the first case all of the packages installed in your system Python will be available in the virtualenv, but any package that you install in the virtualenv will mask the version in your system Python while the virtualenv is active. It doesn't matter whether you create the virtualenv using virtualenv MY_ENV or virtualenv -no-site-packages MY_ENV.
The version of the package that you install will be the active package version for the virtualenv. Yes, when your virtualenv is active you need to install your required package using distutils the "normal" Python installation method ( python setup.py install), or with a virtualenv aware tool (e.g.
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